目的　探讨十二指肠乳头部肿瘤的定性诊断与分期 ,提高十二指肠乳头部肿瘤局部切除术的疗效。方法　回顾性分析 2 9例行局部切除的十二指肠乳头肿瘤的临床、病理资料。结果　钳夹活检对十二指肠乳头癌的诊断符合率为 55 6%。T1期腺癌的中位生存期显著性长于T2 、T3 期腺癌 (分别为 57个月和 3 1个月 )。结论　肿瘤局部切除术适用于良性十二指肠乳头肿瘤以及早期的十二指肠乳头癌 ;选用肿瘤局部切除术时 ,不能单纯依赖于十二指肠镜检查和钳夹病理结果 ,还需依据术中探查、冰冻病理结果以及术后病理结果采取相应的措施 Objective To investigate the qualitative diagnosis and staging of duodenal papillary tumors and to improve the efficacy of local excision of duodenal papilla. Methods The clinical and pathological data of 29 cases of locally resected duodenal papillary tumors were retrospectively analyzed. Results The coincidence rate of biopsy on duodenal papillary carcinoma was 55.6%. The median survival of stage T1 adenocarcinoma was significantly longer than that of stage T2 and T3 adenocarcinoma (57 and 31 months, respectively). Conclusion Tumor resection for benign duodenal papillary tumors and early duodenal papillary carcinoma; selection of tumor resection, can not simply rely on duodenoscopy and pathology results, but also based on Intraoperative exploration, frozen pathological results and postoperative pathological results to take appropriate measures