米非司酮是一种抗孕激素甾体激素,通过与孕激素竞争受体而起到强效抗孕激素的作用,可用于抗早孕,与米索前列醇配伍,使抗早孕完全流产率达90％以上,并已被大量临床研究所验证。本研究通过光镜及电镜观察,探讨米非司酮对胎盘绒毛的形态学影响;分析及探讨米非司酮对绒毛染色体有无致突变作用,从而导致胚胎畸形。 Mifepristone is an anti-progesterone steroid hormone that acts as a potent antiprogestational hormone by competing with progesterone receptors for anti-early pregnancy and misoprostol, resulting in a complete abortion rate for early pregnancy More than 90%, and has been a large number of clinical studies have been verified. In this study, morphological changes of placenta villi were observed by light microscope and electron microscope observation. The effects of mifepristone on the chromosomal aberrations were analyzed and the embryonic malformations were induced.