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目的探讨维C银翘片辅助治疗儿童过敏性紫癜的临床疗效、安全性及其对免疫球蛋白影响。方法 104例过敏性紫癜患儿,采用随机数字表法分为观察组与对照组,各52例。对照组给予单纯西医常规治疗;观察组在对照组基础上给予维C银翘片辅助常规治疗,两组均以4周为1个疗程。检测干预前后血清免疫球蛋白(Ig G、Ig A)水平,观察两组患儿临床症状体征变化及治疗不良反应,评价临床效果与临床用药的安全性。结果观察组总有效率为94.23%(49/52),对照组为73.08%(38/52),观察组明显高于对照组,差异具有统计学意义(χ~2=4.372,P<0.05)。干预前两组患儿的血清Ig A、Ig G水平比较差异无统计学意义(P>0.05);干预后两组患儿的血清Ig A、Ig G水平改善均低于干预前,且观察组Ig A、Ig G水平改善显著低于对照组,差异均有统计学意义(P<0.05)。两组患儿均没有发生严重的不良反应,观察组患儿中出现5例服药后胃部不适,在治疗结束后不适症状均明显好转。结论维C银翘片能够显著调节过敏性紫癜儿童的免疫球蛋白水平,其治疗过敏性紫癜患儿的临床机理考虑与抑制抗原抗体反应有密切关系。
Objective To investigate the clinical curative effect and safety of vitamin C Yinqiao Tablet on children with Henoch-Schonlein purpura and its influence on immunoglobulin. Methods 104 cases of children with Henoch-Schonlein purpura were randomly divided into observation group and control group with 52 cases in each group. The control group was treated with conventional western medicine only. The observation group was given routine treatment of vitamin C Yinqiao tablets on the basis of the control group. Both groups were given a course of treatment for 4 weeks. Serum immunoglobulin (Ig G, Ig A) levels were measured before and after intervention. Clinical symptoms and signs and adverse reactions were observed in both groups to evaluate the clinical efficacy and safety of clinical medication. Results The total effective rate was 94.23% (49/52) in the observation group and 73.08% (38/52) in the control group. The observation group was significantly higher than that of the control group (χ ~ 2 = 4.372, P <0.05) . There was no significant difference in serum Ig A and Ig G levels between the two groups before intervention (P> 0.05). Serum Ig A and Ig G levels in both groups were significantly lower than those before intervention Ig A, Ig G levels were significantly lower than the control group, the difference was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. Five patients in the observation group developed stomach discomfort after taking the medicine, and symptoms were significantly improved after the treatment. Conclusion Wei C Yinqiao tablet can significantly regulate immunoglobulin levels in children with allergic purpura and its clinical mechanism of treatment for children with Henoch-Schonlein purpura is closely related to the inhibition of antigen-antibody reaction.