目的:探讨阿霉素能否导致粘液表皮样癌MEC-1凋亡,为口腔涎腺肿瘤的化疗提供资料.方法:通过细胞染色用光镜、电镜观察10 mg/L.阿霉素作用下MEC～1细胞形态的变化.流式细胞仪检测MEC～1细胞受药物作用后的DNA变化.结果:在光镜、电镜下MEC～1细胞形态上显现一系列典型的凋亡特征性变化,流式细胞仪所测结果示有凋亡细胞存在.结论:阿霉素可诱导MEC～1细胞凋亡,为口腔涎腺肿瘤化疗提供了一个细胞凋亡模型. Objective: To investigate whether doxorubicin can induce the apoptosis of mucoepidermoid carcinoma MEC-1 and provide information for chemotherapy of oral salivary gland tumors.Methods: The cells were stained with light and electron microscope for 10 mg / L doxorubicin The changes of the morphology of MEC-1 cells were detected by flow cytometry.Results: The typical morphological changes of MEC-1 cells were observed under light and electron microscopes, The results of flow cytometry showed apoptotic cells existed.Conclusion: Adriamycin can induce the apoptosis of MEC-1 cells and provide a model of apoptosis for oral salivary gland tumor chemotherapy.