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以不同的实验条件分为以下五组观察肾脏细胞保护作用现象.1.空白对照组:腹腔注射生理盐水.2.阳性对照组:腹腔注射Hgcl_2得到肾损伤模型.3.PGE_2+Hgcl_2组:先给PGE_2,接着再给Ngcl_2,观察到肾损伤减轻.4.消炎痛+Hgcl_2:予先给予消炎痛,阻断PGs合成,再注射Hgcl_2,显示肾损伤加重.表明PGE_2对肾脏具有细胞保护作用.5.两次用汞组.给动物先注射一次小剂量Hgcl_2,再给以大剂量Hgcl_2,这样的动物,比单用一次大剂量Hgcl_2对肾损伤为轻.表明肾脏可能也具有适应性细胞保护作用.
Different experimental conditions were divided into the following five groups to observe the phenomenon of renal cell protection. 1. Blank control group: intraperitoneal injection of saline. 2. Positive control group: intraperitoneal injection of Hgcl 2 to obtain renal injury model. 3. PGE_2+Hgcl_2 group: first To PGE_2, and then to Ngcl_2, to observe the reduction of renal damage. 4. Indomethacin + Hgcl_2: pre-administration of indomethacin, blocking the synthesis of PGs, and then injected Hgcl_2, showing increased renal injury. PGE_2 showed a cytoprotective effect on the kidney. 5. Use the mercury group twice. Give the animal a small dose of Hgcl_2 first, and then give a large dose of Hgcl_2. Such an animal is lighter than a single dose of Hgcl_2 on renal damage, indicating that the kidney may also have adaptive cell protection. effect.