论文部分内容阅读
目的研究外源性IL-10对小儿牙龈炎组织中IL-6和细胞间黏附分子-1(ICAM-1)表达的影响。方法选取2012年5月~2014年6月在该院接受治疗的80例牙龈炎患儿和正常进行健康检查的儿童40名为研究对象。根据探诊深度及附着丧失实施分组,轻度牙龈炎组简称轻度组、重度牙龈炎组简称重度组,各40例,选取同期在该院进行健康检查的儿童40名为对照组。对比各组IL-6含量水平,各组ICAM-1含量水平,分析外源性IL-10与IL-6及ICAM-1的相关性。结果重度组IL-6含量水平均高于其他两组,经过治疗后重度组及轻度组的IL-6含量水平均降低,但治疗7天后仍显著高于对照组的水平,差异均有统计学意义(均P<0.05)。重度组的ICAM-1含量水平均分别显著高于轻度组和对照组,经过治疗后,重度组及轻度组的ICAM-1含量水平均降低,但治疗7天后仍显著高于对照组的水平,差异均有统计学意义(均P<0.05)。通过Spearman法分析相关性可知,外源性IL-10与IL-6及ICAM-1均呈显著负相关。结论外源性IL-10能够较好地降低小儿牙龈炎组织关于IL-6及ICAM-1的表达,值得临床进一步深入研究。
Objective To investigate the effect of exogenous interleukin-10 (IL-10) on the expression of IL-6 and ICAM-1 in children with gingivitis. Methods From May 2012 to June 2014, 80 children with gingivitis and 40 children with normal health examination were enrolled in this study. According to the depth of exploration and attachment loss implementation group, mild gingivitis group referred to as mild group, severe gingivitis group referred to as severe group, each 40 cases, select the same period in the hospital for health examination of 40 children as the control group. The level of IL-6, the level of ICAM-1 in each group were compared, and the correlation between exogenous IL-10, IL-6 and ICAM-1 was analyzed. Results The levels of IL-6 in severe group were higher than those in the other two groups. After treatment, the levels of IL-6 in severe group and mild group decreased, but were still significantly higher than those in control group after 7 days of treatment Significance (both P <0.05). ICAM-1 levels in severe group were significantly higher than those in mild group and control group, respectively. After treatment, ICAM-1 levels in severe group and mild group were decreased, but were still significantly higher than those in control group after 7 days Level and difference were statistically significant (all P <0.05). By Spearman analysis of correlation, exogenous IL-10 and IL-6 and ICAM-1 showed a significant negative correlation. Conclusion Exogenous IL-10 can reduce the expression of IL-6 and ICAM-1 in gingivitis tissue in children, which deserves further study in clinic.