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目的:观察七箭方提取物对大鼠糖尿病肾病的影响,并比较其与七箭方饮片疗效的不同。方法:选择雄性SD大鼠予链脲佐菌素65mg/kg单次腹腔注射诱发糖尿病,观察糖尿病大鼠灌服不同剂量七箭方提取物、七箭方饮片、卡托普利90天后,血糖、血脂、肾功能、肾指数、肾小球滤过率、肾脏病理的改变。结果:糖尿病大鼠灌服七箭方提取物后,血糖、血脂、肾功能、肾指数、肾脏病理明显改善(P<0.05或P<0.01),疗效优于七箭方饮片。结论:七箭方提取物对糖尿病肾病的疗效优于饮片。
OBJECTIVE: To observe the effect of Qijianfang extract on diabetic nephropathy in rats, and to compare the effect of Qijianfang extract with Qijianfang decoction. METHODS: Male Sprague-Dawley rats were selected for intraperitoneal injection of streptozotocin (65 mg/kg) to induce diabetes. Diabetic rats were given different doses of Qijianfang extract, Qijianfang decoction, and captopril for 90 days. Blood lipids, renal function, kidney index, glomerular filtration rate, renal pathological changes. RESULTS: After gavage of Qijianfang extract from diabetic rats, blood glucose, blood lipids, renal function, kidney index and renal pathology were significantly improved (P<0.05 or P<0.01), and the curative effect was better than that of Qijianfang. Conclusion: The effect of Qijianfang extract on diabetic nephropathy is better than that of decoction.