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目的了解海洛因静脉药瘾者HGV HCV重叠感染状况。方法用酶联免疫间接法 ,逆转录套式聚合酶性反应 (RT -nPCR)分别检测 10 7例静脉药瘾者抗 -HCV、HCVRNA、HGVRNA。结果抗 -HCV(+ )者HGVRNA(+ )检出率达 48.15 % ,而抗 -HCV(- )者则为 2 2 .6 4% ,两组比较 ,差异有极显著意义 (X2 =7.5 9,P <0 .0 1)。在HGV HCV重叠感染者中 ,单项抗 -HCV(+ )与HCVRNA(+ )两组差异无显著意义 (X2 =0 .2 1,P >0 .0 5 ) ,男女性别差异也无统计学意义 (X2 =0 .0 7,P >0 .0 5 )。结论海洛因静脉药感者HGV/HCV重叠感染率显著高于非药瘾之丙型肝炎患者 ,其重叠感染率与HCV活动性和感染时间以及性别无关。
Objective To understand the status of HGV HCV overlap infection among heroin addicts. Methods The anti-HCV, HCV RNA and HGVRNA of 107 intravenous drug addicts were detected by enzyme-linked immunosorbent assay and reverse transcriptase-mediated polymerase chain reaction (RT -nPCR). Results The detection rate of HGV RNA (+) in anti-HCV (+) patients was 48.15%, while that in anti-HCV patients was 2.26%. There was significant difference between the two groups (X2 = 7.59 , P <0. 01). There was no significant difference between single anti-HCV (+) and HCVRNA (+) in HGV HCV co-infected patients (X2 = 0.21, P> 0.05) (X2 = 0 .0 7, P> 0 .0 5). Conclusions Overweight infection rate of HGV / HCV in heroin intravenous flu patients is significantly higher than that of non-drug addicted hepatitis C patients. The overlapping infection rate has no relation with HCV activity, infection time and sex.