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目的:探讨血管生成素-2及其受体Tie2在肾透明细胞癌中的表达及与肿瘤血管生成、肿瘤组织发生、发展之间的关系。方法:应用免疫组织化学SP法,分别检测80例肾透明细胞癌组织及10例癌旁组织中血管生成素-2,Tie2及CD34的表达,根据CD34染色结果计算微血管密度。结果:肾透明细胞癌组织中血管生成素-2、Tie2阳性表达率分别为61.25%,58.75%,均明显高于癌旁组织(P<0.05);血管生成素-2和Tie2的表达与肾透明细胞癌患者血尿、临床分期以及淋巴结转移密切相关(P<0.05);血管生成素-2和Tie2阳性表达组微血管密度均高于阴性表达组(P<0.05)。结论:血管生成素-2和Tie2在肾透明细胞癌发生和转移过程中起重要作用,并与肿瘤血管生成关系密切。
Objective: To investigate the expression of angiopoietin-2 and its receptor Tie2 in renal clear cell carcinoma and its relationship with tumor angiogenesis, tumorigenesis and development. Methods: Immunohistochemical SP method was used to detect the expression of angiopoietin-2, Tie2 and CD34 in 80 cases of renal clear cell carcinoma and 10 cases of paracancerous tissues. The microvessel density was calculated according to the result of CD34 staining. Results: The positive rates of Angiopoietin-2 and Tie2 in renal clear cell carcinoma tissues were 61.25% and 58.75%, respectively, which were significantly higher than those in paracancerous tissues (P <0.05). The expressions of Angiopoietin-2 and Tie2 in renal clear cell carcinoma were significantly higher than those in renal The hematuria, clinical stage and lymph node metastasis in patients with clear cell carcinoma were closely related (P <0.05). The microvessel density in both Angiopoietin-2 and Tie2-positive groups were higher than those in negative group (P <0.05). Conclusion: Angiopoietin-2 and Tie2 play an important role in carcinogenesis and metastasis of renal clear cell carcinoma and are closely related to tumor angiogenesis.