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目的评价新生儿期短肠综合征患儿远期营养状况和智力发育状况。方法2005年11月～2006年3月间对我院1988年1月1日～2003年12月31日15年间收治的9例出生后28d内诊断为短肠综合征,并且已脱离静脉营养至少2年的患儿进行随访。随访内容包括人体测量、血液生化指标和智商测定。结果9例患儿中,1例3岁时车祸意外死亡,其余8例得到患儿本人及家长同意随访。8例患儿中,7例年龄、身高、体重正常,1例患儿肥胖,患儿体脂含量为11.1%～24.9%,血液生化指标如血红蛋白、白蛋白、免疫球蛋白均正常,1例患儿前白蛋白(Pre-ALB)低于正常(0.14g/L),1例平均红细胞体积(MCV)高于正常(103.3 fl),1例MCV低于正常(78.3 fl)。7例患儿智力发育均处于正常水平,但3例患儿存在智商分离现象,1例患儿学校成绩处于班级下游。结论短肠综合征患儿脱离静脉营养后的远期营养状况基本正常,但仍然存在问题,全面随访应坚持到静脉营养停用后的整个生长发育时期。智力发育值得重视,应纳入随访内容。
Objective To evaluate the long-term nutritional status and mental development of neonates with short-bowel syndrome. Methods From November 2005 to March 2006, 9 cases admitted to our hospital from January 1, 1988 to December 31, 2003 in 15 years were diagnosed as short bowel syndrome within 28 days after birth and were separated from the vein nutrition 2 years of follow-up of children. Follow-up includes anthropometry, blood biochemical markers and IQ tests. Results Of the 9 children, 1 died of an accident at the age of 3 and the other 8 were given the consent of their own parents and their follow-up. Among the 8 children, 7 were normal in age, height and weight, 1 was obese. The body fat content in children was 11.1% ~ 24.9%. The blood biochemical indexes such as hemoglobin, albumin and immunoglobulin were all normal. One patient Pre-ALB in children was lower than normal (0.14g / L), mean MCV was higher than normal (103.3 fl), and MCV in one was lower than normal (78.3 fl). Seven cases of children with intellectual development were at normal levels, but there are three cases of IQ separation of children, one case of children in the school grades in the lower reaches of the class. Conclusion The long-term nutritional status of children with short-bowel syndrome after leaving the vein nutrition is basically normal, but there are still problems, and full follow-up should be maintained until the period of growth and development after the intravenous nutrition is disabled. Intellectual development deserves attention, should be included in the follow-up content.