一、肾素的抑制肾素与血管紧张素原的反应是AngⅡ形成过程的第一步,也是其限速步骤。由于只有血管紧张素原是肾素的天然底物,抑制此反应就可特异地干扰肾素-血管紧张素系统,肾素抑制剂用于临床治疗可能也是有益的,因它没有AngⅡ拮抗剂或CE抑制剂的那些局限性。二、肾素抑制剂的结构及体外活性胃酶抑素(pepstatin)是来自微生物的肽,它是肾素的弱抑制剂。 First, the inhibition of renin Renin reaction with angiotensinogen Ang Ⅱ formation process is the first step, but also the rate-limiting step. Since only angiotensinogen is a natural substrate for renin, inhibition of this reaction can specifically interfere with the renin-angiotensin system and renin inhibitors may also be beneficial for clinical treatment because it does not have an Ang II antagonist or Those limitations of CE inhibitors. Structure and in vitro activity of renin inhibitors Pepstatin is a peptide derived from microorganisms that is a weak inhibitor of renin.