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目的通过对中国长春市和日本名取市集团筛查前列腺癌对比性研究,揭示两国人群中前列腺癌病理学特征。方法长春市15 192名和名取市4 444名人群中50岁以上的男性应用血清PSA检测进行前列腺癌的集团筛查,对血清PSA含量>4.0ng/ml阳性候选者行前列腺穿刺活检。结果(1)长春市人群中筛状腺癌为42.4%(42/99),名取市为18.3%(21/115)(P<0.01);长春市人群中小腺泡腺癌为29.3%(29/99),名取市为73.9%(85/115)(P<0.01);(2)长春市人群中低分化腺癌为64.7%(64/99),名取市24.3%(28/ 115)(P<0.01),长春市中分化腺癌为33.3%(33/99),名取市为72.2%(83/115)(P<0.01);(3)长春市人群中43.4%(43/99)的腺癌出现神经周围浸润,而名取市为7.0%(8/115)(P<0.01);长春市人群中11.1%(11/99)腺癌出现被膜浸润,而名取市未发现被膜浸润(P<0.01)。结论(1)长春市人群中前列腺腺癌较名取市以低分化癌为主;(2)长春市人群中进展期前列腺癌较名取市人群中多。
OBJECTIVE: To compare the prostate cancer screening of Changchun City in China and Nishimo City in Japan to reveal the pathological features of prostate cancer in the two countries. Methods A total of 15 192 men and 4 444 men in the city of Changchun were enrolled in this study. Serum PSA was used for group screening of prostate cancer. Prostate biopsy was performed on positive candidates with serum PSA> 4.0 ng / ml. Results (1) The rate of adenocarcinoma of the bladder in Changchun was 42.4% (42/99), the name of the city was 18.3% (21/115) (P <0.01) / 99), the prevalence was 73.9% (85/115) (P <0.01); (2) The prevalence of poorly differentiated adenocarcinoma was 64.7% (64/99) in Changchun and 24.3% (28/115) P <0.01). The average prevalence of differentiated adenocarcinoma in Changchun was 33.3% (33/99), and the prevalence was 72.2% (83/115) (P <0.01); (3) 43.4% Of the adenocarcinoma showed peripheral nerve infiltration, while the name of the market was 7.0% (8/115) (P <0.01). In 11.1% (11/99) adenocarcinoma of Changchun city, there was infiltration of the adenocarcinoma, P <0.01). Conclusions (1) Prostate adenocarcinoma in Changchun city is more differentiated than that in Minchuan city. (2) Prostate cancer in Changchun population is more than that in Ming dynasty.