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甘露醇(mannitol, MT)是一种渗透性利尿剂,广泛应用于临床各科如神经科、外科、妇产科、眼科、儿科、肾脏科以及重症病人的救治,用以降低颅内压、眼压、利尿等,既往认为MT无不良副作用,但近年来因应用不当导致急性肾功能衰竭(acute renal failure, ARF)的病例报道显著增多。据汪光煜统计,在国内药物中毒所致ARF的原因中甘露醇居第三位,仅次于氨基糖甙类抗生素、安眠药,属严重的医源性疾病,不仅对患者造成不必要的伤害、增加了患者的痛苦,而且容易造成医疗纠纷。可见其危害很大,是临床应重点防范的疾病。现将1980～2002年间国内公开发表的81篇甘露醇导致的1234例ARF文献荟
Mannitol (MT), an osmotic diuretic, is widely used in clinical departments such as neurology, surgery, obstetrics and gynecology, ophthalmology, pediatrics, nephrology and critically ill patients to reduce intracranial pressure, Intraocular pressure, diuretic, etc., in the past that MT no adverse side effects, but in recent years due to improper use lead to acute renal failure (ARF) cases were significantly increased. According to Wang Guangyu statistics, the cause of ARF caused by drug poisoning in the third mannitol, second only to aminoglycoside antibiotics, sleeping pills, is a serious iatrogenic disease, not only caused unnecessary harm to the patient, increased The patient’s pain, but also easily lead to medical disputes. Shows its great harm, is the clinical focus should be to prevent the disease. Now from 1980 to 2002 domestic published 81 mannitol caused 1234 cases of ARF literature Hui