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Wilson和Sutherland于1981年报告,在新西兰Auckland市两年来因急性哮喘发作而死亡的病例骤增,并认为可能与该地区近年来更改以往惯用的哮喘治疗方案有关。特别与广泛使用口服长效茶碱以替代吸入皮质类激素和色甘酸钠有关。认为高剂量茶碱类药物与吸入β_2受体激动剂并用,可能导致心搏骤停。Wilson等报告80年5月至81年2月突然心搏停止的25例中,只有3例经心肺复苏获救,平均年龄为25岁。而1974～1978年同一地区哮喘病死者年龄小于45岁的只占50%,说明哮喘患者不仅突然死亡的数字增加,而且年龄也相应提前。作者认为这与年青人愿意改为只用茶碱类药物与β_2受体激动剂有关。
Wilson and Sutherland reported in 1981 that a sudden increase in the number of deaths from acute asthma attacks in Auckland, New Zealand, over the past two years, is believed to be linked to changes in the region’s past practice of asthma treatment in recent years. Especially with the widespread use of oral long-acting theophylline to replace inhaled corticosteroids and cromolyn sodium related. It is believed that high-dose theophylline and inhaled β 2 receptor agonist may lead to cardiac arrest. Of the 25 patients who reported sudden cardiac arrest from May 1980 to February 1981, only 3 were rescued by CPR with an average age of 25 years. However, in the same area from 1974 to 1978, only 50% of those who died of asthma were younger than 45 years old, indicating that not only the number of sudden death in asthma patients increased, but also the age in advance. The authors believe this is related to the willingness of young people to switch to theophylline-only beta-2 agonists.