论文部分内容阅读
目的考察多孔羟基磷灰石微球对药物的吸附性质。方法采用溶液吸附法研究市售羟基磷灰石微球对药物的吸附性质。以氯化锶为标记物,用扫描电镜-能谱分析仪定点扫描微球内锶的分布情况,氮吸附法测定微球的比表面积和孔径。结果可与羟基磷灰石上的钙离子螯合的药物吸附量相对较高,而依靠氢键或电荷间相互作用、发生物理吸附的药物吸附量偏低,难溶性药物吸附药量普遍低于水溶性药物。市售微球孔径约为30 nm,属于介孔材料,药物多分布在微球的表层。结论阐明了羟基磷灰石微球对不同类型药物的吸附特征,为其作为药物载体提供依据。
Objective To investigate the adsorption properties of porous hydroxyapatite microspheres to drugs. Methods The adsorption properties of commercial hydroxyapatite microspheres on drug were studied by solution adsorption method. With strontium chloride as a marker, the distribution of strontium in the microspheres was detected by SEM and EDS. The specific surface area and pore size of the microspheres were determined by nitrogen adsorption. As a result, the amount of drug adsorbed on the calcium ion on the hydroxyapatite was relatively high, whereas the number of the drug adsorbed by the physical adsorption on the hydrogen bond or the charge-charge interaction was low, and the amount of the drug adsorbed on the hardly soluble drug was generally lower than Water-soluble drugs. Microsphere diameter of about 30 nm commercially available, are mesoporous materials, drugs are distributed in the surface of the microspheres. Conclusion The adsorption characteristics of hydroxyapatite microspheres to different types of drugs were clarified, which provided the basis for their application as drug carriers.