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转录因子激活蛋白-1是由亮氨酸拉链类蛋白构成的同源/异源二聚体,是诸多信号转导途径在细胞核内的交汇点,在慢性阻塞性肺疾病、支气管哮喘和肺间质纤维化等慢性炎症性疾病的发生、发展过程中有重要作用。其作用机制包括调控转录、磷酸化及蛋白质的相互作用,涉及炎性细胞因子、黏附分子、谷胱甘肽、蛋白酶等的表达调控及炎性细胞的活化,还参与哮喘对糖皮质激素抵抗的发生。
Transcription factor activator protein-1 is a homologue / heterodimer composed of leucine zipper class proteins and is the meeting point of many signal transduction pathways in the nucleus. In chronic obstructive pulmonary disease, bronchial asthma and pulmonary Fibrosis and other chronic inflammatory diseases, the development process has an important role. Its mechanism of action includes regulation of transcription, phosphorylation and protein interactions involving the regulation of the expression of inflammatory cytokines, adhesion molecules, glutathione, proteases and the activation of inflammatory cells, as well as the involvement of asthma in glucocorticoid resistance occur.