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目的观察希罗达单药治疗老年晚期消化道肿瘤的疗效和毒副反应。方法希罗达2000mg/m2.d,分2次,餐后服用,连续服用14d后停药7d,21d为1个周期,至少治疗2个周期。结果37例均可评价疗效,总有效率29.7%,临床获益率73.0%。主要毒副反应为手足综合征、色素沉着、消化道反应、白细胞下降等。结论希罗达单药治疗老年晚期消化道肿瘤安全、有效,用药方便,不良反应轻。
Objective To observe the efficacy and side effects of Xeloda monotherapy in elderly patients with advanced gastrointestinal tumors. Methods Xeloda 2000mg / m2.d, divided into 2 times, taking after meals, taking 14d after continuous withdrawal 7d, 21d for a cycle, at least two cycles of treatment. Results All 37 cases were evaluated. The total effective rate was 29.7% and the clinical benefit rate was 73.0%. The main side effects of hand-foot syndrome, pigmentation, digestive tract reactions, leukopenia and so on. Conclusion Xeloda monotherapy in the treatment of elderly patients with advanced gastrointestinal cancer is safe and effective, with convenient medication and mild adverse reactions.