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目的:观察盐酸吡柔比星(THP)膀胱内灌注预防浅表性膀胱肿瘤术后复发的疗效。方法:将68例膀胱肿瘤患者分实验组和对照组进行临床研究,完成为期4 a的随访观察。结果:实验组比对照组的1 a、2 a、3 a无瘤生存率都有显著性提高。结论:THP是一种新型的、有效的、安全性好的膀胱腔内化疗药物,对预防浅表性膀胱肿瘤术后复发有良好的作用。
Objective: To observe the curative effect of intravesical instillation of pirarubicin hydrochloride (THP) in preventing postoperative recurrence of superficial bladder tumor. Methods: 68 cases of bladder cancer patients were divided into experimental group and control group for clinical study, to complete a 4-year follow-up observation. Results: The tumor-free survival rate of the experimental group was significantly higher than that of the control group at 1 a, 2 a, 3 a. Conclusion: THP is a new, effective and safe intravesical chemotherapeutic drug, which has a good effect on the prevention of postoperative recurrence of superficial bladder tumor.