本研究借助玻璃微电极,在离体心室乳头肌细胞上完成。在一定条件下,用克山病病区粮喂养动物容易引起心肌细胞电反应变化(APA 和 RP 降低、APD 缩短、Vmax 下降),但用锌前处理后,有些变化明显减轻;锌对心肌的保护作用是竞争性抑制心肌细胞膜的慢通道影响Ca~(2+)内流、降低心肌细胞内 Ca~(2+)负荷所致;提示在克山病病区人群增加锌的摄入量,可能有助于预防克山病, This study was performed on isolated papillary cells in vitro using glass microelectrodes. Under certain conditions, animals fed with food from Keshan disease easily induced changes in cardiomyocyte electrical response (APA and RP decreased, APD shortened, Vmax decreased), but some changes significantly reduced after zinc pretreatment; zinc on myocardial The protective effect is that competitive inhibition of the slow pathway of myocardial cell membrane affects the influx of Ca ~ (2+) and decreases the Ca ~ (2 +) load in cardiomyocytes. It is suggested that the increase of zinc intake in Keshan disease area, May help prevent Keshan disease,