恶性黑棘皮病是较少见的病例,我院于1982年收治一例,除具有一般典型皮肤粘膜表现外,尚伴有食管下段癌及胃小弯癌,对此病例我们作了皮肤活检及电子显微镜观察,报告如下。患者、男性、63岁,主诉皮肤发黑18个月,吞咽困难13个月。患者于18个月前发现前额部有4×9cm皮肤发黑区域,以后逐渐发展,按顺序为面、颈、躯 Vicious acanthosis is a rare case. In our hospital in 1982, except for the typical skin and mucous membrane performance, it was accompanied by lower esophageal cancer and gastric cancer. We made a skin biopsy and electron in this case. Microscope observations are reported below. The patient, male, 63 years old, complained of dark skin for 18 months and dysphagia for 13 months. The patient discovered that the forehead had 4×9 cm dark areas of the skin 18 months before, and gradually developed. The order was face, neck, and torso.