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目的探讨中性粒细胞/淋巴细胞比值(NLR)与DR的相关性。方法 随机选取2014年1~12月于安徽省阜阳市人民医院内分泌科住院的T2DM患者310例,分为无DR(NDR)组118例及DR组192例,其中,DR组根据有无增殖期病变再分为非增殖期DR(NPDR)亚组134例及增殖期DR(PDR)亚组58例。分析各组临床资料、NLR及生化指标。结果与NDR组比较,DR组年龄、病程、SBP、FPG、HbA_1c、TC、TG、LDL-C、Scr、高敏C反应蛋白(hsC-RP)、胱抑素-C(Cys-C)、中性粒细胞计数(NC)及NLR均升高,HDL-C降低(P<0.05)。与NPDR亚组比较,PDR亚组病程、HbA_1c、Scr、hsCRP、NC及NLR均升高,HDL-C降低(P<0.05)。Logistic回归分析显示,病程、FPG、HbA_1c、TG、LDL-C、HDL-C、hsC-RP、Cys-C及NLR是影响DR发生的相关因素。受试者工作特征(ROC)曲线显示,NLR与DR的关系优于hsC-RP、Cys-C炎症指标,且NLR在NDR组、NPDR亚组及PDR亚组逐渐升高[(1.52±0.26)vs(1.68±0.21)vs(1.95±0.17),P<0.05]。结论 NLR与DR发生及严重程度相关。
Objective To investigate the correlation between neutrophil / lymphocyte ratio (NLR) and DR. Methods A total of 310 T2DM patients admitted to Department of Endocrinology, People’s Hospital of Fuyang City, Anhui Province from January to December 2014 were randomly divided into 118 cases without DR (NDR) group and 192 cases with DR group. Among them, The lesions were further divided into non-proliferative phase DR (NPDR) subgroup 134 cases and proliferative phase DR (PDR) subgroup 58 cases. The clinical data, NLR and biochemical indexes of each group were analyzed. Results Compared with NDR group, the age, course of disease, SBP, FPG, HbA_1c, TC, TG, LDL-C, Scr, hsC-RP, Neutrophil count (NC) and NLR increased, while HDL-C decreased (P <0.05). Compared with the NPDR subgroup, the duration of PDR subgroup, HbA 1c, Scr, hsCRP, NC and NLR increased, and HDL-C decreased (P <0.05). Logistic regression analysis showed that the duration of disease, FPG, HbA 1c, TG, LDL-C, HDL-C, hsC-RP, Cys-C and NLR were the related factors that affected the occurrence of DR. The receiver operating characteristic (ROC) curve showed that the relationship between NLR and DR was better than that of hsC-RP and Cys-C, and the level of NLR in NDR group, NPDR subgroup and PDR subgroup increased gradually [(1.52 ± 0.26) vs (1.68 ± 0.21) vs (1.95 ± 0.17), P <0.05]. Conclusion NLR is related to the occurrence and severity of DR.