施用化学药物杀灭钉螺 ,仍是阻断血吸虫病流行的关键措施之一。氯硝柳胺是国外首选的、唯一商品化的高效低毒的灭螺药物 [1]。但它与现有灭螺药物一样 ,在疫区使用时 ,往往会遇到缺乏水源或远离水源的问题。而且喷洒灭螺持效期短 ,喷药后如遇大雨 ,效果更差。为了提高灭螺效果 The use of chemical drugs to kill snails, is still one of the key measures to block the epidemic of schistosomiasis. Niclosamide is the first choice abroad, the only commercially available high efficiency and low toxicity of snail drugs [1]. However, like the existing snail drugs, it often encounters the problem of lack of or away from water sources when used in affected areas. Spraying mollusc and holding a short duration, spraying in case of heavy rain, the effect is even worse. In order to improve the snail effect