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目的探讨肾康注射液对维持性血液透析老年患者氧化应激及炎性因子水平的影响。方法将88例肾衰竭维持性血液透析老年患者随机分为两组,每组44例;在常规治疗基础上,对照组维持血液透析,观察组同时结合肾康注射液静脉滴注治疗,疗程4周。检测两组治疗前后患者肾功能、氧化应激及炎性因子各项指标变化情况。结果 1肾功能:治疗后观察组Scr、BUN、Ccr较治疗前显著改善(P<0.05),且其改善优于对照组(P<0.05);2应激反应指标:治疗后观察组MDA、SOD、T-AOC、GSH-Px较治疗前明显改善(P<0.05),且其改善优于对照组(P<0.05);3炎性因子:治疗后观察组炎性因子CRP、IL-6、IL-8、TNF-α水平较治疗前均明显降低(P<0.05),且观察组炎性因子水平均低于对照组(P<0.05)。结论肾康注射液可改善维持性血液透析老年患者肾功能、氧化应激及炎症状态。
Objective To investigate the effects of Shenkang injection on oxidative stress and inflammatory cytokines in elderly patients with hemodialysis. Methods Eighty-eight elderly patients with renal failure and maintenance hemodialysis were randomly divided into two groups (44 in each group). On the basis of routine treatment, the control group was maintained hemodialysis. The observation group was treated with intravenous infusion of Shenkang injection. The treatment 4 week. The changes of renal function, oxidative stress and inflammatory cytokines in both groups before and after treatment were detected. Results 1 Renal function: After treatment, Scr, BUN and Ccr in the observation group were significantly improved (P <0.05), and their improvement was better than that in the control group (P <0.05) .2 Stress response index: After treatment, The levels of SOD, T-AOC and GSH-Px were significantly improved (P <0.05), and the improvement was better than that of the control group (P <0.05) .3 Inflammatory factors: The levels of inflammatory cytokines CRP and IL- , IL-8 and TNF-α were significantly lower than those before treatment (P <0.05), and the levels of inflammatory cytokines in the observation group were lower than those in the control group (P <0.05). Conclusion Shenkang injection can improve renal function, oxidative stress and inflammatory status in elderly patients with maintenance hemodialysis.