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目的研究不同级别胶质瘤中P53和Ki-67的表达情况,进而分析它们在胶质瘤恶性变及发生、发展中的关系。方法将42例胶质瘤标本依据WHO 2000神经外科肿瘤分类标准进行分类,分为低级别组和高级别组,按照免疫组化方法即SP二步法对胶质瘤标本及10例正常脑组织标本进行P53和Ki-67的表达情况的检测。结果 P53及Ki-67的表达与胶质瘤的恶性程度有关(P<0.05)。结论 P53和Ki-67的表达情况可以作为评价胶质瘤恶性程度的生物学指标。
Objective To study the expression of P53 and Ki-67 in different grades of gliomas, and to analyze the relationship between the expression of P53 and Ki-67 in gliomas. Methods 42 glioma specimens were classified according to WHO 2000 classification of neurosurgical tumors and divided into low-grade group and high-grade group. According to the immunohistochemical method (SP two-step method), glioma specimens and 10 normal brain tissues Specimens were examined for the expression of P53 and Ki-67. Results The expression of P53 and Ki-67 were correlated with the malignant degree of glioma (P <0.05). Conclusion The expression of P53 and Ki-67 can be used as biological indicators to evaluate the malignant degree of glioma.