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暴发性肝衰竭(FHF)并颅内高压的病人伴有肾功能衰竭而对甘露醇和超滤法无迅速疗效时,死亡率>90%。资料显示,苯巴比妥能控制头部外伤所致的颅内高压(IH)。故作者选取13例 FHF,其中11例的FHF 因自杀服扑热息痛所致,2例为非甲非乙型肝炎所致,13例均有3～4级肝性脑病,合并急性肾功能衰竭(尿量<20ml/h),且对甘露醇和超滤法无效,先用静脉慢滴硫喷妥钠(TP)15分钟,直至 IH 症状消失或已达500mg 极量为止。随后以最小量静滴维持,以颅内压(ICP)<20mmHg 和脑灌流压>50mmHg 为
In patients with fulminant hepatic failure (FHF) and intracranial hypertension associated with renal failure and no immediate effect on mannitol and ultrafiltration, mortality was> 90%. Data show that phenobarbital can control head injury caused by intracranial hypertension (IH). Therefore, the authors selected 13 cases of FHF, of which 11 cases of FHF suicide with paracetamol due to 2 cases of non-A non-hepatitis B, 13 cases have grade 3 to 4 hepatic encephalopathy, with acute renal failure (urine Volume <20ml / h), and the mannitol and ultrafiltration ineffective, first with intravenous drip thiopental (TP) 15 minutes until IH symptoms disappear or has reached 500mg very much. Followed by a minimum amount of intravenous maintenance, intracranial pressure (ICP) <20mmHg and cerebral perfusion pressure> 50mmHg