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目的 分析 PAG在肌梭传入镇痛中的作用及有关的神经递质。方法 以大鼠脊髓背角广动力型 (WDR)神经元伤害性诱发反应 (C-反应 )为痛指标 ,采用细胞外记录单位放电、核团损毁及核团内微量注射药物的方法 ,观察静脉注射琥珀胆碱 (SCH)所诱发的肌梭传入对 WDR神经元 C-反应的影响。结果 静脉注射 SCH可兴奋大多数 PAG神经元的自发放电活动 ,而对WDR神经元 C-反应呈明显的抑制作用 ;损毁双侧 PAG腹外侧区后 ,静脉注射 SCH对 WDR神经元 C-反应呈明显的抑制作用 ;损毁双侧 PAG腹外侧区后 ,静脉注射 SCH对 WDR神经元 C-反应的抑制分别呈现减弱、减弱、增强作用。结论 PAG在肌梭传入镇痛中起着重要作用 ;阿片肽类物质及 γ-氨基丁酸能神经元参与了 PAG在肌梭传入镇痛中的作用
Objective To analyze the role of PAG in the induction of muscle spindle into the analgesia and related neurotransmitters. Methods WDR neurons were used as pain index in spinal cord dorsal horn. Discharge of extracellular recording unit, nucleus rupture and microinjection of drugs into the nucleus were observed. Intravenous Effect of Muscle Shuttle Induced by Injection of Choline (SCH) on C-Reaction of WDR Neurons. Results Intravenous injection of SCH stimulated the spontaneous discharge activity of most PAG neurons and significantly inhibited the C-response of WDR neurons. After the ventrolateral region of bilateral PAG was injured, Obvious inhibitory effect. After the ventrolateral region of bilateral PAG was damaged, the inhibition of C-reaction of WDR neurons by SCH was attenuated, attenuated and enhanced respectively. Conclusions PAG plays an important role in the muscle spindle afferent analgesia. Opioid peptides and γ-aminobutyric acid can participate in the role of PAG in muscle spindle delivery