论文部分内容阅读
目的:观察胃癌组织c-Jun氮末端激酶(JNK)和血管内皮生长因子-C(VEGF-C)表达,分析其与临床病理学指标之间的关系及两者的相关性。方法:采用免疫组化SP法检测41例胃癌组织和10例正常胃组织JNK和VEGF-C的表达。结果:JNK在41例胃癌组织的阳性表达率为78.0%,在10例正常胃组织的阳性表达率为30.0%,两者比较差异有统计学意义,P<0.05。VEGF-C在胃癌组织的阳性表达率为80.5%,在正常胃组织的阳性表达率为10.0%,两者比较差异有统计学意义,P<0.05。JNK的阳性表达与胃癌是否有淋巴结转移及肿瘤大小相关,P值均<0.05。VEGF-C与胃癌是否有淋巴结转移及胃癌早晚分期相关,P值均<0.05。JNK和VEGF-C在胃癌组织中的表达具有一定相关性,r=0.457,P<0.01。结论:JNK可以用来评价胃癌淋巴结转移与肿瘤的大小,VEGF-C表达可评估胃癌组织的分期和淋巴结转移。联合检测胃癌组织中JNK和VEGF-C的表达可作为其评估预后的指标。
OBJECTIVE: To observe the expression of c-Jun N-terminal kinase (JNK) and vascular endothelial growth factor-C (VEGF-C) in gastric cancer, and to analyze the relationship between them and clinicopathological parameters and their correlation. Methods: Immunohistochemical SP method was used to detect the expression of JNK and VEGF-C in 41 cases of gastric cancer tissues and 10 cases of normal gastric tissues. Results: The positive expression rate of JNK in 41 cases of gastric cancer was 78.0% and in 10 cases of normal gastric tissues was 30.0%, the difference was statistically significant (P <0.05). The positive expression rate of VEGF-C in gastric cancer was 80.5% and that in normal gastric tissue was 10.0%, the difference was statistically significant (P <0.05). The positive expression of JNK correlated with lymph node metastasis and tumor size in gastric cancer (P <0.05). VEGF-C and gastric cancer have lymph node metastasis and gastric cancer sooner or later stage related, P values were <0.05. JNK and VEGF-C expression in gastric cancer has a certain correlation, r = 0.457, P <0.01. Conclusion: JNK can be used to evaluate the lymph node metastasis and tumor size in gastric cancer. The expression of VEGF-C can be used to evaluate the staging and lymph node metastasis of gastric cancer. Combined detection of JNK and VEGF-C expression in gastric cancer can be used as an indicator of prognosis.