关节软骨对机械应力的反应包括液体流动瞬时相和以流体与组织形变为特征的长时相,后者与软骨基质渗透性有关。糖胺多糖(GAGs)是构成软骨基质的重要成分,任何磨损和组织退化均可影响其生物力学性质导致软骨组织破坏。本文就不同龄大鼠关节盘在不 The response of articular cartilage to mechanical stresses includes the instantaneous phase of fluid flow and the long phase characterized by fluid and tissue deformation, the latter being related to the permeability of the cartilage matrix. Glycosaminoglycans (GAGs) constitute an important component of the cartilage matrix, and any wear and degradation of the tissue can affect their biomechanical properties leading to cartilage tissue destruction. In this paper, different age rat disc in the absence