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本文是从人体分离出G型肉毒杆菌及其毒素的首次报告。检出本菌的5例都是骤然死亡的男性。1例系18周婴儿,4例自24～45岁。婴儿病例死于哺乳后2小时,4例成人于就寝后约7～10小时被发现已死亡。从发病到死亡当晚就寝相隔1、2小时～3天。临床上有苍白、恶心、软弱、纳差、眩晕、咳嗽、上腹疼痛、严重口渴、口及咽部极度干燥等表现。解剖发现有严重的出血性肺水肿、支气管肺炎、严重的心肌间质水肿、严重的肝、脾、肾、脑充血等。从心、血、肺、小肠、心肌、肝、脾、大肠、肾等内脏共分离到19株G型肉毒杆菌。从婴儿例及2名成人的血清还检出了该菌型的特异性肉毒杆菌毒素。
This article is the first to report the isolation of botulinum type G and its toxins from the human body. Five cases of this bacteria were detected in sudden death of men. One case of 18 weeks of infants, 4 cases from 24 to 45 years old. Baby cases died 2 hours after lactation and 4 adults were found dead at about 7 to 10 hours after bedtime. From onset to death that night separated by 1,2 hours to 3 days. Clinical pale, nausea, weakness, anorexia, dizziness, cough, abdominal pain, severe thirst, mouth and pharynx extremely dry and so on. Anatomy found severe hemorrhagic pulmonary edema, bronchial pneumonia, severe myocardial interstitial edema, severe liver, spleen, kidney, cerebral congestion and so on. From the heart, blood, lung, small intestine, myocardium, liver, spleen, large intestine, kidney and other internal organs were isolated 19 strains of Botulinum type G. Specific botulism toxins of this bacterium were also detected from infant and 2 adult sera.