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<正>1文献来源Hanem LGE,Stridsklev S,Júlíusson PB,et al.Metformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age:Follow-up of two RCTs[J]. J Clin Endocrinol Metab,2018,103（4）:1612-1621.2证据水平1a。3背景·多囊卵巢综合征（polycystic ovary syndrome,PCOS）可影响5%～13%的育龄女性[1]。