中耳手术的主要问题是使复位的听骨和移植物在愈合过程中能保持在适宜位置而不移动,组织胶粘剂较好地解决了这个难题。2—氰基—丁基—丙烯酸盐(CBA)胶粘剂,因其有组织相容性好、粘合快速、副作用少而倍受重视,然而,既往对CBA的研究多在组织形态学方面,并且对CBA在中耳和内耳的适用性和安全性看法各异。本研究试图证明CBA或其降解产物有无潜在的耳毒性,通过豚鼠的听性脑干 The main problem of middle ear surgery is to make the resetting ossicles and grafts remain in proper position without moving during the healing process. Tissue adhesive solves this problem well. Cyano-butyl-acrylate (CBA) adhesives have attracted much attention because of their good histocompatibility, rapid adhesion and few side effects. However, most of the previous studies on CBA are in histomorphology, and There are different opinions on the applicability and safety of CBA in the middle ear and inner ear. This study attempted to demonstrate the potential of ototoxicity of CBA or its degradation products through the auditory brainstem of guinea pigs