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目的探讨全反式维甲酸联合三氧化二砷治疗初发急性早幼粒细胞白血病的临床疗效。方法将我院在2008-08-2014-09收治的26例初发急性早幼粒细胞白血病患者作为本次的临床研究对象,并将其进行数字化随机分为对照组与观察组2组,每组13例。其中对照组患者采用全反式维甲酸间隙治疗,观察组患者则在对照组的用药基础上增加使用三氧化二砷进行联合治疗。结果观察组患者的症状完全缓解时间、出血症状消失时间、凝血指标恢复正常时间以及早期病死率均较对照组更具优势(P<0.05)。结论针对初发急性早幼粒细胞白血病患者,采用全反式维甲酸联合三氧化二砷治疗的效果较为明显,可有效降低患者的早期病死率。
Objective To investigate the clinical efficacy of all-trans retinoic acid combined with arsenic trioxide in the treatment of acute promyelocytic leukemia. Methods Twenty-six patients with newly diagnosed acute promyelocytic leukemia admitted in our hospital from August 2008 to September 2014 were selected as the clinical study subjects and were digitized and divided into 2 groups: control group and observation group. Group of 13 cases. The control group patients with all-trans retinoic acid gap treatment, the observation group patients in the control group based on the use of drugs increased the use of arsenic trioxide for joint treatment. Results The symptom relief time, disappearance of hemorrhagic symptoms, normal time of coagulation index recovery and early mortality in observation group were more superior than those in control group (P <0.05). Conclusion For patients with newly diagnosed acute promyelocytic leukemia, the effect of all-trans retinoic acid combined with arsenic trioxide treatment is more obvious, which can effectively reduce the early mortality of patients.