盐酸普鲁卡因为目前常用的局麻药和静脉麻醉药。我院在制备10％普鲁卡因注射液时,发现成品明显发黄,而且麻醉效果受影响。经探讨,是由于普鲁卡因分子中含有酯键和芳伯胺基结构,所以水溶液不稳定,易被氧化和水解。这与pH值及灭菌时间、温度有密切关系,而光线、氧、金属离子等也能加速其分解反应。我们对此进行了多次实验分析。 Proca Hydrochloride because of the current local anesthetics and intravenous anesthetics. Our hospital in the preparation of 10% procaine injection, the product was found significantly yellow, and the anesthetic effect is affected. After discussion, because the procaine molecules contain ester bonds and primary amine structure, so the aqueous solution is unstable, easily oxidized and hydrolyzed. This is pH value and sterilization time, temperature are closely related, and light, oxygen, metal ions can also accelerate the decomposition reaction. We conducted several experiments on this.