地方性(巴尔干)肾疾患,为一种原因不明的慢性肾曲细管疾病,多见于保加利亚、罗马尼亚和南斯拉夫的某些地区,并常饼有泌尿道肿瘤。本病早期蛋白尿的特征为:低分子蛋白排泄量增多,包括β_2微球蛋白、溶菌酶、轻链和R-b蛋白(Retinol-Binding Protein)。据认为这种蛋白尿主要反映肾曲细管再吸收功能障碍,以及正常可被滤过的低分子蛋白的 Endemic (Balkan) kidney disease, an unexplained chronic renal tubular disease, occurs more frequently in some areas of Bulgaria, Romania and Yugoslavia and often has urinary tumors. The early stage of this disease is characterized by proteinuria: low-molecular protein excretion increased, including β 2 microglobulin, lysozyme, light chain and R-b protein (Retinol-Binding Protein). It is believed that this proteinuria mainly reflects renal tubular reabsorption dysfunction, as well as the normal can be filtered low molecular weight protein