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缩胆囊肽(CCK)是一种兴奋性神经肽,人们发现CCK 在大鼠和人的大脑皮质、海马和基底神经节内有较高浓度。和CCK 结合的部位也密集分布在大脑皮质和基底神经节。作者以前报道过慢性舞蹈病患者的基底神经节和大脑皮质内CCK 受体有显著减少。为了弄清这种CCK 受体丧失现象是否也发生在另一种神经系统退行性疾病中,作者测定了老年性痴呆患者和对照组死后颞叶及扣带回标本内CCK 受体数。从测定结果看,老年性痴呆患者和对照组的CCK 受体数并无显著差异。
Cholecystokinin (CCK) is an excitatory neuropeptide that has been found to have higher concentrations in rat cerebral cortex, hippocampus and basal ganglia in both humans and humans. The site of CCK binding is also densely distributed in the cerebral cortex and basal ganglia. The authors previously reported significant reductions in CCK receptors in basal ganglia and cerebral cortex in patients with chronic chorea. To determine if this CCK receptor loss also occurs in another neurodegenerative disease, we determined the number of CCK receptors in the temporal lobe and cingulate gyrus in patients with Alzheimer’s disease and controls. From the measurement results, there is no significant difference in the number of CCK receptors between patients with Alzheimer’s disease and the control group.