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目的:蛋白酪氨酸磷酸酯酶1B(Protein tyrosine Phosphatase 1B,PTP1B)对胰岛素信号的负性调控作用被认为是治疗2型糖尿病的潜在性靶点。PTP1B在细胞内主要锚定在内质网膜上,并且因其酪氨酸磷酸酯酶的活性在内质网应激(Endoplasmic Reticulum Stress,ERS)信号传导中起着重要的调
OBJECTIVE: The negative regulatory effect of protein tyrosine phosphatase 1B (PTP1B) on insulin signaling is considered as a potential target for the treatment of type 2 diabetes mellitus. PTP1B is mainly anchored in the endoplasmic reticulum membrane in the cell, and plays an important role in endoplasmic Reticulum Stress (ERS) signaling because of its tyrosine phosphatase activity