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目的:探索APC基因突变与新疆维吾尔族、汉族直肠癌的发生及临床病理之间的关系。方法:采用银染PCR-SSCP法检测新疆地区70例原发性直肠腺癌组织及距肿瘤10cm以上的正常粘膜组织中APC基因MCR之碱基突变。结果:70例直肠癌组织中APC基因突变38例(54.3%),APC基因在新疆维吾尔族和汉族直肠癌组织中的突变频率较高,分别为53.6%和57.1%,但两民族之间突变率、突变与各临床病理因素之间的差异均无统计学意义(P>0.05)。结论:新疆地区APC基因MCR突变在民族之间以及和临床病理之间均无相关性。
Objective: To explore the relationship between APC gene mutation and the occurrence of Uygur and Han rectal cancer in Xinjiang and its clinical pathology. Methods: The base mutation of APC gene MCR was detected in 70 cases of primary rectal adenocarcinoma and 10 cm above normal mucosa in Xinjiang by silver staining PCR-SSCP. Results: APC gene mutation was found in 38 cases (54.3%) in 70 cases of rectal cancer and APC gene in 53.6% and 57.1% of Uygur and Han nationalities, respectively. However, the mutation frequency of two ethnic groups There was no significant difference in rates, mutations and clinical pathological factors (P> 0.05). Conclusion: The MCR mutations of APC gene in Xinjiang region have no correlation between ethnic groups and clinicopathological features.