库兴氏综合征的糖代谢紊乱很常见。目前认为与病人存在胰岛素抵抗有关,但其确切机理并不十分清楚。为了解库兴氏综合征的胰岛素抵抗机理是否肥胖症相似,以及库兴氏综合征的糖代谢紊乱与胰岛素抵抗的关系,作者用正常血糖胰岛素钳夹技术对4例库兴氏综合征、6例肥胖症病人及5例正常人的胰岛素反应性及胰岛素清除率进行了研究。 在血糖维持稳定的状态下,当胰岛素输入处于最高剂量(10mu/kg/min)时,正常人的葡萄糖 Cushing’s syndrome is a common disorder of glucose metabolism. Currently considered to be related to the existence of insulin resistance in patients, but the exact mechanism is not very clear. In order to understand whether insulin resistance mechanism of Cushing’s syndrome is similar to obesity and the relationship between glucose metabolism disorder and insulin resistance in Cushing’s syndrome, we used the normal glucose insulin clamp technique to study the relationship between Cushing’s syndrome, Cases of obesity patients and five normal subjects insulin responsiveness and insulin clearance were studied. In the state of stable blood glucose, when the insulin input is at the highest dose (10mu / kg / min), normal human glucose