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目的:观察穴位按摩对海洛因依赖者脱毒不同阶段血清促甲状腺激素(thyroid-stimulating hormone,TSH)、总三碘甲状腺原氨酸(total triiodothyronine,TT_3)与总四碘甲状腺原氨酸(total thyroxine,TT_4)水平的影响。方法:224名海洛因依赖者来自于强制隔离戒毒所,根据其脱毒不同时间段分为急性脱毒期、脱毒巩固期、脱毒康复期、回归社会期四个阶段,并将处于同一脱毒阶段的人员随机分为脱毒对照组与脱毒按摩组。脱毒按摩组人员接受穴位按摩干预12周,脱毒对照组不给予干预。所有被试者分别于干预前、干预8周和12周后接受血清TSH、TT_3、TT_4水平检测。将脱毒各期被试者干预前的血清检测结果与健康对照组进行统计学比较,将脱毒对照组与脱毒按摩组干预前后各指标的差值进行统计学比较。结果:与健康对照组相比,急性脱毒期人员血清TT_3、TT_4显著性降低(P<0.01)。急性脱毒期(女)、脱毒巩固期(男)、回归社会期(男)脱毒按摩组干预8周前后TSH差值与脱毒对照组相比,差异具有显著性(P<0.05);脱毒巩固期(女)脱毒按摩组干预8周前后TT_4、TSH差值与脱毒对照组相比,差异具有显著性(P<0.05);脱毒康复期(男)脱毒按摩组干预8周前后TT_4差值以及12周前后TT_3差值与脱毒对照组相比,差异具有显著性(P<0.05);脱毒康复期(女)脱毒按摩组干预8周前后TT_3、TT_4差值与脱毒对照组相比,差异具有显著性(P<0.05)。结论:海洛因依赖者急性脱毒期甲状腺激素减低;穴位按摩可促进海洛因依赖者脱毒早期TSH、TT_4恢复。该结果提示穴位按摩在戒毒中的作用值得进一步研究。
Objective: To observe the changes of serum thyroid-stimulating hormone (TSH), total triiodothyronine (TT_3) and total thyroxine (total thyroxine) in different stages of detoxification of heroin addicts. , TT_4) level of impact. Methods: A total of 224 heroin addicts were divided into four groups: acute detoxification phase, detoxification consolidation phase, detoxification recovery phase and social reversion period according to different detoxification periods. Toxic stage of the staff were randomly divided into detoxification control group and detoxification massage group. Detoxification massage group acupoint massage intervention for 12 weeks, the virus-free control group without intervention. All subjects received serum TSH, TT_3 and TT_4 levels before intervention and after intervention for 8 and 12 weeks respectively. The results of serum test before intervention were compared statistically with the control group. The differences between before and after intervention in virus-free control group and virus-free massage group were compared statistically. Results: Compared with the healthy control group, serum TT_3 and TT_4 in acute phase of detoxification were significantly lower (P <0.01). The difference of TSH difference between acute detoxification stage (female), detoxification consolidation stage (male), return to social phase (male) detoxification massage group before and after 8 weeks intervention had significant difference (P <0.05) ; Difference of TT_4 and TSH before and after 8-week intervention in detoxification and consolidation (female) detoxification massage group was significant compared with that of detoxification control group (P0.05); detoxification massage group TT_4 difference before and after 8 weeks of intervention and difference of TT_3 before and after 12 weeks showed significant difference compared with control group (P <0.05); TT_3 and TT_4 Compared with the control group, the difference was significant (P <0.05). Conclusion: The thyroid hormones in acute detoxification stage of heroin addicts are reduced. Acupoint massage can promote the recovery of early TSH and TT_4 in heroin dependent patients. The results suggest that the role of acupressure in detoxification deserves further study.