本研究观察了家兔双后足重度冻伤后用蝮蛇抗栓酶（０．２５Ｕ／ｋｇ体重加入２０ｍｌ／ｋｇ体重生理盐水中，耳缘静脉点滴）进行治疗后其血凝系统某些指标的改变。结果表明，重度冻伤后家兔的出血时间及凝血时间明显缩短，血小板功能呈不同程度的改变，血浆纤维蛋白原含量增加，血液处于高凝状态；用蝮蛇抗栓酶治疗后，上述各项指标均有不同程度的改善，结果提示，蝮蛇抗栓酶可明显缓解冻伤所致的血凝增强的病变过程，这对重度冻伤的治疗将起到重要作用 In this study, we observed the hypercoagulability of some indexes of rabbits after severe frostbite of double dorsal hind leg after treatment with viper antithrombin (0.25U / kg body weight in 20ml / kg body weight saline and ear vein) change. The results showed that the bleeding time and coagulation time of rabbits after severe frostbite were significantly shortened, the platelet function changed to some extent, the content of plasma fibrinogen increased, and the blood was hypercoagulable. After treatment with viper snake antithrombin, The indexes all improved to some extent. The results suggest that viper antithrombotic enzyme can obviously relieve the enhanced blood coagulation process induced by frostbite, which will play an important role in the treatment of severe frostbite