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The effects of minimally invasive surgery on the blood-brain barrier (BBB) of 30 patients with cerebral hemorrhage were investigated. Difference of the BBB index and serum MBP concentration were assessed in 15 cases of conservative treatment group and 15 cases of minimally invasive surgery group. The BBB index in minimally invasive surgery group was significantly lower than in conservative treatment group (P＜0.05), and the BBB index in the two treatment groups was significantly higher than in control group (P＜0.01). Serum MBP concentration in minimally invasive surgery group was significantly lower than in conservative treatment group (P＜0.05), and that in the two treatment groups was significantly higher than in control group (P＜0.01). It was suggested the permeability of BBB in patients with cerebral hemorrhage was increased, and BBB index and serum MBP concentration in patients with cerebral hemorrhage were increased. Minimally invasive surgery can reduce the lesion of cytotoxicity to BBB and cerebral edema.