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目的:研究急性冠脉综合征(ACS)冠脉内支架置入后尾加压素Ⅱ(hUⅡ)与院内不良心血管事件(MACE)的关系。方法:将接受冠脉支架置入术ACS 202例,按照有无院内MACE分为观察组29例和对照组173例,比较两组hUⅡ水平差异;采用Logistic回归分析法筛选MACE的危险因素。结果:观察组支架置入后即刻冠状静脉hUⅡ含量(678.45±67.85)pg/ml,对照组(538.21±46.48)pg/ml,两组比较,差异非常显著(P<0.01)。以LDL-C、FBG、吸烟史校正,对观察组支架置入术后冠状静脉hUⅡ水平与冠脉血流速度作偏相关分析,两者呈负相关。结论:ACS患者术后即刻冠状静脉hUⅡ水平升高可能是引发术后院内MACE的原因之一。
Objective: To investigate the relationship between urotensin Ⅱ (hU Ⅱ) and adverse cardiovascular events (MACE) after coronary stenting of acute coronary syndrome (ACS). Methods: 202 ACS patients undergoing coronary stenting were divided into observation group (n = 29) and control group (n = 173) according to the presence or absence of MACE. The difference of hUⅡ level between the two groups was compared. The risk factors of MACE were screened by Logistic regression analysis. Results: The content of hU Ⅱ in coronary vein immediately after stent implantation was 678.45 ± 67.85 pg / ml in the observation group and 538.21 ± 46.48 pg / ml in the control group. The difference was significant (P <0.01). The LDL-C, FBG, smoking history were corrected. The correlation between hUⅡ level in coronary vein and coronary blood flow velocity was negatively correlated with the coronary blood flow velocity after stent implantation. CONCLUSION: Elevated hUⅡ level in coronary venous immediately after ACS may be one of the causes of postoperative in-hospital MACE.