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目的研究低分子肝素结合常规疗法治疗重度子癎前期的疗效及治疗期间母儿各项指标的变化。方法2004-12-2005-12,青岛市第八人民医院选取重度子癎前期患者74例,分为观察组31例(在常规治疗方法同时加用低分子肝素5000IU皮下注射),对照组43例(常规治疗)。观察两组患者临床指标变化。结果观察组较对照组血压下降,尿量增加,尿蛋白总量减少,自觉症状改善,脐动脉血流S/D比值下降,胎儿窘迫、新生儿窒息率下降;两组产后出血量无明显差异。结论低分子肝素结合常规疗法治疗重度子癎前期患者,可显著改善治疗效果。
Objective To study the effect of low molecular weight heparin combined with conventional therapies for the treatment of severe preeclampsia and the changes of maternal and infant indexes during the treatment. Methods From December 2004 to December 2004, 74 patients with severe preeclampsia from Qingdao Eighth People’s Hospital were selected and divided into observation group (n = 31) (subcutaneously injected with low molecular weight heparin (5000IU) in routine treatment), and control group (n = 43) (Conventional treatment). The changes of clinical indexes in two groups were observed. Results Compared with the control group, the observation group had lower blood pressure, increased urine output, decreased total proteinuria, improvement of symptoms, decreased S / D ratio of umbilical artery blood flow, fetal distress, and neonatal asphyxia. There was no significant difference in postpartum hemorrhage between the two groups . Conclusion Low molecular weight heparin combined with conventional therapy in patients with severe preeclampsia can significantly improve the therapeutic effect.