论文部分内容阅读
心肌组织一直被认为是不可再生组织,对其损伤后的治疗一般也只能采用保守方法。近年来,在成年大鼠心脏中发现的Lin-c-kit POS细胞有向心肌细胞分化的潜力,说明成年机体心肌组织中仍可能存在干细胞;而对胚胎干细胞及骨髓干细胞在修复损伤心肌方面的相关研究也显示这些干细胞可通过分化成心肌细胞而改善心肌功能;对多种细胞因子的广泛研究也发现其能促进心肌细胞的分裂增生,多种研究结果提示心肌再生并非不可能。虽然在后续的几个大规模临床前研究中未能取得令人期待的结果,以及伦理问题和机体对不同干细胞的免疫排斥反应等问题仍待解决,但心肌再生的研究前景仍然光明。
Myocardial tissue has always been considered as non-renewable tissue, its treatment after injury generally only conservative method. In recent years, Lin-c-kit POS cells found in adult rat hearts have the potential to differentiate into cardiomyocytes, indicating that stem cells may still exist in adult myocardial tissues. However, the effects of embryonic stem cells and bone marrow stem cells in repairing injured myocardium Related research also shows that these stem cells can improve myocardial function by differentiating into cardiomyocytes. Extensive research on various cytokines has also found that they can promote the proliferation and proliferation of cardiomyocytes. Many studies suggest that myocardial regeneration is not impossible. Although the failure to achieve the desired result in several large-scale preclinical studies in the follow-up period, as well as the ethical issues and the immune rejection reaction of different stem cells by the body remains to be solved, the research prospect of myocardial regeneration remains bright.