This paper presents a review of the state-of-the-art research and its applications developed at Hohai University relating to the hydrodynamic and morphological processes in the Yangtze Estuary.Longitudinal, lateral,and horizontal flow circulations have been revealed based on the measurements with acoustic Doppler current profilers (ADCP).The hydrodynamic mechanism at diversion points as well as the changing patterns of flow and sediment flux in the Yangtze Estuary has been investigated through long-term data analysis.A field survey has been carried out to detect the saltwater intrusion from the North Branch to South Branch. Different numerical models of flow motion, sediment transport, and saltwater intrusion have been developed to simulate the complicated processes and to evaluate the effects of engineering projects. The morphological processes of wetlands over a time scale of decades have been analyzed with an established database. Ideas for further research on the bio-geomorphological model system and long-term evolution mechanisms are put forward. This paper presents a review of the state-of-the-art research and its applications developed at Hohai University relating to the hydrodynamic and morphological processes in the Yangtze Estuary. Longitudinal, lateral, and horizontal flow circulations have been revealed based on the measurements with acoustic Doppler current profilers (ADCP). The hydrodynamic mechanism at diversion points as well as the changing patterns of flow and sediment flux in the Yangtze Estuary has been investigated through long-term data analysis. A field survey has been carried out to detect the saltwater intrusion from the North Branch to South Branch. Different numerical models of flow motion, sediment transport, and saltwater intrusion have been developed to simulate the complicated processes and to evaluate the effects of engineering projects. The morphological processes of wetlands over a time scale of decades have been analyzed with an established database. Ideas for further research on the bio-geomorphologic al model system and long-term evolution mechanisms are forward.