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目的 :探讨转移抑制基因nm2 3与大肠癌特别是无转移大肠癌病人预后的关系。方法 :应用免疫组化ABC法检测nm2 3蛋白产物核苷二磷酸激酶 (DNPK)在大肠癌中的表达。分析其与肿瘤生物学特征的相关性以及其与预后关系。结果 :nm2 3 NDPK的阳性表达率为 6 7 3% (6 8 10 1) ,其表达与肿瘤分化相关性无显著意义 ,与病理分期显著相关。nm2 3基因的表达与生存率呈正相关 ,与转移复发率呈负相关 (P <0 0 5 )。Ⅰ、Ⅱ期病例中nm2 3(- )者复发转移率亦高于nm2 3(+)者 (P <0 0 5 )。结论 :nm2 3 NDPK可作为大肠癌预后的判断指标。nm2 3 NDPK的低表达预示着肿瘤的侵袭和转移潜能较高
Objective: To investigate the relationship between metastasis suppressor gene nm23 and the prognosis of colorectal cancer, especially in non-metastatic colorectal cancer patients. Methods: The expression of nm23 protein nucleoside diphosphate kinase (DNPK) in colorectal carcinoma was detected by immunohistochemical ABC method. Analyze its correlation with tumor biological characteristics and its relationship with the prognosis. Results: The positive expression rate of nm23 NDPK was 67.3% (6 8 10 1). There was no significant correlation between the expression of nm23 NDPK and tumor differentiation, which was significantly correlated with the pathological stage. The expression of nm23 gene was positively correlated with the survival rate and negatively correlated with the recurrence rate (P <0.05). The recurrence and metastasis rates of nm23 (-) in stage I and II were also higher than those in nm23 (P <0 05). Conclusion: nm2 3 NDPK can be used as a prognostic indicator of colorectal cancer. The low expression of nm23 NDPK predicts the higher invasion and metastasis potential of tumors