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目的 观察维生素A对早产儿免疫功能的调节作用。方法 采用流式细胞术检测早产儿维生素A治疗观察组、早产儿对照组各 1 0例外周血淋巴细胞亚群比例的动态变化 ,并与 8例足月儿比较。结果 早产儿每日服用维生素A 1 50 0IU 2周后 ,总T细胞、T辅助细胞及CD8+T细胞分别从 ( 80 4 0± 5 2 8)、( 61 80± 5 75)、( 2 1 60± 5 1 0 ) %下降到 ( 63 80± 6 3 0 )、( 48 0 0± 4 57)、( 1 7 60± 4 2 5) % ,而总B细胞及NK细胞分别从( 1 0 4 0± 4 84 )、( 5 60± 4 90 ) %上升到 ( 1 7 80± 8 0 4 )、( 1 8 2 0± 7 0 7) % ,与早产儿对照组有明显区别 ,高于足月儿水平。结论 维生素A的短期治疗能促进早产儿的免疫功能成熟。
Objective To observe the regulatory effect of vitamin A on immune function in premature infants. Methods Flow cytometry was used to detect the dynamic changes of the proportion of peripheral blood lymphocyte subsets in 10 cases of vitamin A treatment group and premature infant control group and compared with 8 full-term infants. Results After pretreatment with vitamin A 1 50 IU daily for 2 weeks, the total T cells, T helper cells and CD8 + T cells in preterm infants were increased from (80 4 0 ± 5 2 8), (61 80 ± 5 75), (2 1 (60 ± 5 1 0)% to (63 80 ± 6 3 0), (48 0 0 ± 4 57) and (1 7 60 ± 4 2 5)%, respectively, while total B cells and NK cells decreased from (10 4 0 ± 4 84), (60 ± 4 90)% increased to (17 80 ± 8 0 4) and (18 20 ± 7 0 7)% respectively, which were significantly different from those of the control group Full-term children’s level. Conclusion The short-term treatment of vitamin A can promote the immune function of premature infants.