The practical design of the cable-stayed bridge of the 3rd Macao-Taipa bridge is investigated by the finite element analysis program ANSYS, and 3-D elements BEAM188 and BEAM4 are adopted to create a dynamic calculation model. In order to analyze the material nonlinear seismic response of the cable-stayed bridge, the nonlinear behaviors of the ductile plastic hinges of the bridge towers are taken into account by employing the nonlinear rotational spring element COMBIN40. To simulate a major earthquake, three earthquake records were chosen using a wave-choosing program and input into the bridge structure along longitudinal and transversal directions. Comparisons of the linear and nonlinear seismic responses of the cable-stayed bridge are performed. In addition, a study of TMD primary control is carried out using element MASS21 and element COMBIN14, and it is indicated that the effects of mitigation monitoring are evident.