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局部注射国产肉毒杆菌A(BTX-A)治疗眼睑痉挛12例,单侧面肌痉挛15例,综合征4例,共31例治疗后随访5~12个月,进行病情评估,结果表明治疗后病情好转是显著的,p<0.001。有效率达97%,基本无全身反应及过敏反应,局部副作用轻,短暂,可复,药效作用时间6~28周,多为12~16周。可追加注射,在3~6个月后重复注射,亦取得疗效。临床观察表明,BTX-A治疗局限型肌张力障碍确为一种安全、疗效高、操作方便易行的治疗手段,能在一段时间内缓解甚至消除肌肉痉挛及相关症状。总结积累经验,更好服务于患者。
Local injection of domestic botulinum toxin A (BTX-A) in 12 cases of blepharospasm, unilateral hemifacial spasm in 15 cases, syndrome in 4 cases, a total of 31 cases were followed up for 5 to 12 months after treatment, the disease evaluation, the results showed that after treatment Condition improvement was significant, p <0.001. Effective rate of 97%, the basic no systemic reactions and allergic reactions, local side effects of light, transient, complex, the role of pharmacodynamic time of 6 to 28 weeks, mostly for 12 to 16 weeks. Can be additional injection, in 3 to 6 months after repeated injections, also achieved efficacy. Clinical observations show that BTX-A treatment of focal dystonia is indeed a safe, efficient, easy to operate and easy to treat, can relieve or even eliminate muscle spasms and related symptoms over a period of time. Summarize accumulated experience, better service to patients.