论文部分内容阅读
质子泵抑制剂因其强大的抑酸效果,现已成为全球十大用量最多的药物之一,并存在很多超说明书外的用法。由于超说明书外使用没有统一用法用量的规定,且没有法律的约束和保护,临床使用需要循证医学的评价和指导。笔者通过查阅国内外指南、文献、DRUGDEXsystem,总结质子泵抑制剂(PPIs)临床适应证以及标示外使用的情况,采用GRADE卫生保健的系统对现有证据给出评价及推荐意见。
Proton pump inhibitors because of its strong inhibitory effect, has now become the world’s top ten most used drugs, and there are many super-usage outside the specification. Because there is no uniform use of the rules beyond the manual, and no legal constraints and protection, clinical use requires evidence-based medicine evaluation and guidance. The author uses the GRADE health care system to evaluate and recommend the available evidence by referring to domestic and foreign guidelines, literature, DRUGDEXsystem, summarizing the clinical indications of proton pump inhibitors (PPIs) and using it outside the mark.